6gfm: Difference between revisions
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==Crystal structure of the Escherichia coli nucleosidase PpnN (pppGpp-form)== | |||
<StructureSection load='6gfm' size='340' side='right'caption='[[6gfm]], [[Resolution|resolution]] 2.77Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gfm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GFM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0O2:GUANOSINE+5-(TETRAHYDROGEN+TRIPHOSPHATE)+3-(TRIHYDROGEN+DIPHOSPHATE)'>0O2</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6gfl|6gfl]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gfm OCA], [http://pdbe.org/6gfm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gfm RCSB], [http://www.ebi.ac.uk/pdbsum/6gfm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gfm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PPNN_ECOLI PPNN_ECOLI]] Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base. Can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates. Cannot catalyze the reverse reactions. Is required for optimal growth in glucose minimal medium, possibly because it contributes to nucleoside pool homeostasis by degrading excess nucleotides and feeding back the ribose moiety to catabolism.<ref>PMID:27941785</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Baerentsen, R L]] | |||
[[Category: Brodersen, D E]] | |||
[[Category: Gerdes, K]] | |||
[[Category: Zhang, Y]] | |||
[[Category: Allosteric enzyme]] | |||
[[Category: Antibiotic tolerance]] | |||
[[Category: Fluoroquinolone]] | |||
[[Category: Hydrolase]] | |||
[[Category: Nucleotide metabolism]] | |||
[[Category: Persistence]] | |||
[[Category: Ppnn]] | |||
[[Category: Stringent response]] | |||
[[Category: Ygdh]] | |||
Revision as of 06:47, 24 April 2019
Crystal structure of the Escherichia coli nucleosidase PpnN (pppGpp-form)
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