4qyy: Difference between revisions
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==Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State== | ==Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State== | ||
<StructureSection load='4qyy' size='340' side='right' caption='[[4qyy]], [[Resolution|resolution]] 1.65Å' scene=''> | <StructureSection load='4qyy' size='340' side='right'caption='[[4qyy]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qyy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QYY FirstGlance]. <br> | <table><tr><td colspan='2'>[[4qyy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QYY FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3G7:(3R)-1-{2-[4-(4-ACETYLPHENYL)PIPERAZIN-1-YL]-2-OXOETHYL}-N-(3-CHLORO-4-HYDROXYPHENYL)PYRROLIDINE-3-CARBOXAMIDE'>3G7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3G7:(3R)-1-{2-[4-(4-ACETYLPHENYL)PIPERAZIN-1-YL]-2-OXOETHYL}-N-(3-CHLORO-4-HYDROXYPHENYL)PYRROLIDINE-3-CARBOXAMIDE'>3G7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mapk1, Erk2, Mapk, Prkm1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qyy OCA], [http://pdbe.org/4qyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qyy RCSB], [http://www.ebi.ac.uk/pdbsum/4qyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qyy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qyy OCA], [http://pdbe.org/4qyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qyy RCSB], [http://www.ebi.ac.uk/pdbsum/4qyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qyy ProSAT]</span></td></tr> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4qyy" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4qyy" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Buffalo rat]] | |||
[[Category: Large Structures]] | |||
[[Category: Mitogen-activated protein kinase]] | [[Category: Mitogen-activated protein kinase]] | ||
[[Category: Annis, D A]] | [[Category: Annis, D A]] | ||
