User:Madeleine Wilson/Sandbox 1: Difference between revisions
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==Inhibitors== | ==Inhibitors== | ||
[[Image:Sinefugin.png|200px|left|thumb|Figure 3. Sinefungin]] | [[Image:Sinefugin.png|200px|left|thumb|Figure 3. Sinefungin]] | ||
Sinefungin is a potent methyltransferase inhibitor. It is a structural analog of S-adenosylmethionine that is more stable due to the ability to create two additional hydrogen bonds to its amine group in the active site. It has been used experimentally to inhibit the SET 7/9 protein on peritoneal fibrosis in mice and in human peritoneal mesothelial cells. <ref name="Schluck">PMID: 8995524</ref> | Sinefungin is a potent methyltransferase inhibitor. It is a structural analog of S-adenosylmethionine that is more stable due to the ability to create two additional hydrogen bonds to its amine group in the active site. It has been used experimentally to inhibit the SET 7/9 protein on peritoneal fibrosis in mice and in human peritoneal mesothelial cells. <ref name="Schluck">PMID: 8995524</ref> Studies found that sinefungin suppressed the cell accumulation and thickening in methylglyoxal peritoneal fibrosis. <ref name="Tamura">PMID: 29723250</ref> | ||
</StructureSection> | </StructureSection> | ||
