Toxin Tx7335: Difference between revisions
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== Toxin Tx7335: A Three Finger Protein == | |||
<scene name='81/814055/Bucandin_of_the_3ftx_family/9'>(3FTx)</scene> | |||
This is a default text for your page '''Toxin Tx7335'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Toxin Tx7335'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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Nonconventional 3FTx will have cysteines located at the 3rd, 6th, 11th, 17th, 24th, 39th, 43rd, 55th, 56th, and 61st positions. Conventional 3Ftx lack cysteines at the 6th and 11th position. The disulfide bonds will form between the 3rd and 24th positions, 6th and 11th positions, 17th and 39th positions, 43rd and 55th positions, and the 56th and 61st positions in nonconventional 3FTx, and conventional 3Ftx will lack the cysteine bond between the 6th and 11th positions (3). There is a single known 3FTx isolated from eastern green mamba venom called Tx7335 that doesn’t maintain the conventional cysteine pattern in the other 3FTx. It switches the location of a cysteine for a tyrosine at the 43rd position where all other known 3FTx proteins have a cysteine. The cysteine is replaced in the 25th position where most other 3FTx proteins have a tyrosine. The probable location for the new disulfide bond in this protein would be between the 26th and 54th cysteines (3). | Nonconventional 3FTx will have cysteines located at the 3rd, 6th, 11th, 17th, 24th, 39th, 43rd, 55th, 56th, and 61st positions. Conventional 3Ftx lack cysteines at the 6th and 11th position. The disulfide bonds will form between the 3rd and 24th positions, 6th and 11th positions, 17th and 39th positions, 43rd and 55th positions, and the 56th and 61st positions in nonconventional 3FTx, and conventional 3Ftx will lack the cysteine bond between the 6th and 11th positions (3). There is a single known 3FTx isolated from eastern green mamba venom called Tx7335 that doesn’t maintain the conventional cysteine pattern in the other 3FTx. It switches the location of a cysteine for a tyrosine at the 43rd position where all other known 3FTx proteins have a cysteine. The cysteine is replaced in the 25th position where most other 3FTx proteins have a tyrosine. The probable location for the new disulfide bond in this protein would be between the 26th and 54th cysteines (3). | ||
