6myd: Difference between revisions
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==Structure of zebrafish TRAF6 in complex with STING CTT== | |||
<StructureSection load='6myd' size='340' side='right'caption='[[6myd]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6myd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MYD FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6myd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6myd OCA], [http://pdbe.org/6myd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6myd RCSB], [http://www.ebi.ac.uk/pdbsum/6myd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6myd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TRAF6_DANRE TRAF6_DANRE]] E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Stimulator of interferon genes (STING) is a key regulator of type I interferon and pro-inflammatory responses during infection, cellular stress, and cancer. Here, we reveal a mechanism for how STING balances activation of IRF3- and NF-kappaB-dependent transcription and discover that acquisition of discrete signaling modules in the vertebrate STING C-terminal tail (CTT) shapes downstream immunity. As a defining example, we identify a motif appended to the CTT of zebrafish STING that inverts the typical vertebrate signaling response and results in dramatic NF-kappaB activation and weak IRF3-interferon signaling. We determine a co-crystal structure that explains how this CTT sequence recruits TRAF6 as a new binding partner and demonstrate that the minimal motif is sufficient to reprogram human STING and immune activation in macrophage cells. Together, our results define the STING CTT as a linear signaling hub that can acquire modular motifs to readily adapt downstream immunity. | |||
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kappaB Signaling Adaptation.,de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ Cell Rep. 2019 Apr 23;27(4):1165-1175.e5. doi: 10.1016/j.celrep.2019.03.098. PMID:31018131<ref>PMID:31018131</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6myd" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: RING-type E3 ubiquitin transferase]] | |||
[[Category: Kagan, J C]] | |||
[[Category: King, D S]] | |||
[[Category: Kranzusch, P J]] | |||
[[Category: Lee, A S.Y]] | |||
[[Category: Mann, C C.de Oliveira]] | |||
[[Category: Orzalli, M H]] | |||
[[Category: Immune system]] | |||
[[Category: Innate immunity]] | |||
[[Category: Nf-kappab]] | |||
[[Category: Sting]] | |||
[[Category: Tmem173]] | |||
[[Category: Traf6]] | |||
Revision as of 08:53, 1 May 2019
Structure of zebrafish TRAF6 in complex with STING CTT
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