Sandbox Reserved 1546: Difference between revisions
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==Function== | ==Function== | ||
In order to better understand the function of this 5H86 enzyme, we have to understand the basic processes of Fatty Acid Degradation. Fatty Acid Degradation is the procedure that fatty acids go through to be broken down into their metabolites and it takes place in the mitochondrial matrix. Intermediates in fatty acid breakdown are covalently attached to the sulfhydryl group of coenzyme A. | In order to better understand the function of this 5H86 enzyme, we have to understand the basic processes of Fatty Acid Degradation. Fatty Acid Degradation is the procedure that fatty acids go through to be broken down into their metabolites and it takes place in the mitochondrial matrix. Intermediates in fatty acid breakdown are covalently attached to the sulfhydryl group of coenzyme A. | ||
<p>Fatty Acid Degradation happens in | <p>Fatty Acid Degradation happens in three steps:</p> | ||
<p> 1. '''Lipolysis and release from adipose tissue''': In the initial steps of degradation, fatty acids are stored in adipocytes. The breakdown of adipocytes is called lipolysis (They are released into blood stream to circulate through body.)</p> | <p> 1. '''Lipolysis and release from adipose tissue''': In the initial steps of degradation, fatty acids are stored in adipocytes. The breakdown of adipocytes is called lipolysis (They are released into blood stream to circulate through body.)</p> | ||
<p> 2. '''Activation and transport into mitochondria''': The mitochondria is where fatty acid oxidation occurs which activates fatty acids to be carried to the mitochondria. The enzyme responsible for the catalysis of this step is Fatty-Acyl Coa Synthetase. Malonyl ACP is the activated donor of two carbon units in the elongation step which is operated by the release of CO2.</p> | <p> 2. '''Activation and transport into the mitochondria''': The mitochondria is where fatty acid oxidation occurs which activates fatty acids to be carried to the mitochondria. The enzyme responsible for the catalysis of this step is Fatty-Acyl Coa Synthetase. Malonyl ACP is the activated donor of two carbon units in the elongation step which is operated by the release of CO2.</p> | ||
<p>3. '''Β-oxidation''': Once inside mitochodria, five steps occur: 1) Activation by ATP, 2) Oxydation by FAD, 3) Hydration, 4) Oxydation by NAD+, and 5) Thyolysis. The final product is Acetyl-Coa which is now able to be able to enter the TCA cycle <ref name="Berg, J. M."/>. </p> | <p>3. '''Β-oxidation''': Once inside mitochodria, five steps occur: 1) Activation by ATP, 2) Oxydation by FAD, 3) Hydration, 4) Oxydation by NAD+, and 5) Thyolysis. The final product is Acetyl-Coa which is now able to be able to enter the TCA cycle <ref name="Berg, J. M."/>. </p> | ||
