Sandbox Reserved 1546: Difference between revisions
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='''5H86: HUMAN GCN-5 BOUND TO BUTYRYL-COA'''= | ='''5H86: HUMAN GCN-5 BOUND TO BUTYRYL-COA'''= | ||
This project was completed by Marianne Javier, Karima MuhummadPoe, and Makayla Yang for Dr. Gluick's Spring 2019 BIOL4100K-01 class at Georgia Gwinnett College. | This project was completed by Marianne Javier, Karima MuhummadPoe, and Makayla Yang for Dr. Gluick's Spring 2019 BIOL4100K-01 class at Georgia Gwinnett College. | ||
<p>'''Project Purpose:''' We chose this molecule due to its role as a histone acetyltransferase and its role in transcription regulation<ref>doi: 10.1107/S2059798316007907</ref>. It has a harder time having successful enzymatic activity if the acyl-chain is too long which is the purpose of studying the molecule. These researchers made two different acyl-CoA molecules, propionyl-CoA and butyryl-CoA. We are looking at the butyryl-CoA which has a conformation that obstructs the lysine from binding. We chose this molecule to see how Gcn5L2 chooses which acyl-chain donor to have the highest enzymatic activity.</p> | <p>'''Project Purpose:''' We chose this molecule due to its role as a histone acetyltransferase and its role in transcription regulation <ref>doi: 10.1107/S2059798316007907</ref>. It has a harder time having successful enzymatic activity if the acyl-chain is too long which is the purpose of studying the molecule <ref>doi: 10.1107/S2059798316007907</ref>. These researchers made two different acyl-CoA molecules, propionyl-CoA and butyryl-CoA <ref>doi: 10.1107/S2059798316007907</ref>. We are looking at the butyryl-CoA which has a conformation that obstructs the lysine from binding. We chose this molecule to see how Gcn5L2 chooses which acyl-chain donor to have the highest enzymatic activity.</p> | ||
==Function== | ==Function== | ||
