Sandbox Reserved 1546: Difference between revisions
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<p>One of the enzymes that have a key role in fatty acid degradation and that is also our enzyme of study is known as acyl-CoA acetyltransferase or thiolase. Thiolases are enzymes that have key roles in biochemical pathways and can either be degrative or biosynthetic. Degrative thiolases such as 3-ketoacyl-CoA thiolase, plays a role in fatty-acid β-oxidation in peroxisomes and mitochondria and ketone body metabolism in mitochondria, whereas biosynthetic thiolases, like acetoacetyl-CoA thiolase, catalyzes Acetoacetyl-CoA to two Acetyl-CoAs.</p> | <p>One of the enzymes that have a key role in fatty acid degradation and that is also our enzyme of study is known as acyl-CoA acetyltransferase or thiolase. Thiolases are enzymes that have key roles in biochemical pathways and can either be degrative or biosynthetic. Degrative thiolases such as 3-ketoacyl-CoA thiolase, plays a role in fatty-acid β-oxidation in peroxisomes and mitochondria and ketone body metabolism in mitochondria, whereas biosynthetic thiolases, like acetoacetyl-CoA thiolase, catalyzes Acetoacetyl-CoA to two Acetyl-CoAs.</p> | ||
<p>[[Image:Thiolase_reaction.PNG|400px|center]]</p> | <p>[[Image:Thiolase_reaction.PNG|400px|center]]</p> | ||
<p>Figure 1: | <p><center>'''Figure 1''': Catalysis of Acetoacetyl-CoA to two Acetyle-CoAs with the enzyme thiolase. Image obtained from class powerpoints.</center></p> | ||
