Sandbox Reserved 1546: Difference between revisions
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===Disease Relevance=== | ===Disease Relevance=== | ||
Since this enzyme is found in ''Homo sapiens'', or humans, and is a HAT Gcn5 bound to butyryl-CoA, the 5h86 enzyme has also been found to have a probable role in HIV-1 infections by being able to utilize the recruited viral protein "Tat" to regulate the activity that induces proviral gene chromatin remodeling <ref name = " | Since this enzyme is found in ''Homo sapiens'', or humans, and is a HAT Gcn5 bound to butyryl-CoA, the 5h86 enzyme has also been found to have a probable role in HIV-1 infections by being able to utilize the recruited viral protein "Tat" to regulate the activity that induces proviral gene chromatin remodeling <ref name = "Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity">PMID: 10607594</ref>. The Tat protein is responsible for the activation of the elongation stage of transcription by recruiting certain transcription factor complexes, like pTEFb, and coactivators like p300/CBP <ref name = "Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity"/>. Due to this correlation, the Tat protein may also have capabilities to promote HAT activity of the p300 coactivator which binds to the HIV-1 promoter region <ref name = "Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity"/>. Another similarity is that the HATs acetylate lysine residues (Lys50 and Lys51), just like the 5h86 acetyltransferase <ref name = "Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity"/>. Due to this overall correlation, it is inferred that this 5h86 Gcn5 bound to butyryl-CoA may have a biochemical role in HIV-1 infections. | ||
</StructureSection> | </StructureSection> | ||
