6hyo: Difference between revisions

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'''Unreleased structure'''


The entry 6hyo is ON HOLD
==Structure of ULK1 LIR motif bound to GABARAP==
 
<StructureSection load='6hyo' size='340' side='right'caption='[[6hyo]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
Authors: Mouilleron, S., Wirth, M., Zhang, W., O'Reilly, N., Tooze, S., Johansen, T., Razi, M., Nyoni, L., Joshi, D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6hyo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HYO FirstGlance]. <br>
Description: Structure of ULK1 LIR motif bound to GABARAP
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hyo OCA], [http://pdbe.org/6hyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hyo RCSB], [http://www.ebi.ac.uk/pdbsum/6hyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hyo ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ULK1_HUMAN ULK1_HUMAN]] Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.<ref>PMID:18936157</ref> <ref>PMID:21460634</ref> <ref>PMID:21795849</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Johansen, T]]
[[Category: Joshi, D]]
[[Category: Joshi, D]]
[[Category: Mouilleron, S]]
[[Category: Nyoni, L]]
[[Category: Razi, M]]
[[Category: Razi, M]]
[[Category: Johansen, T]]
[[Category: Reilly, N O]]
[[Category: Zhang, W]]
[[Category: Nyoni, L]]
[[Category: O'Reilly, N]]
[[Category: Tooze, S]]
[[Category: Tooze, S]]
[[Category: Mouilleron, S]]
[[Category: Wirth, M]]
[[Category: Wirth, M]]
[[Category: Zhang, W]]
[[Category: Atg8]]
[[Category: Autophagy]]
[[Category: Lir]]
[[Category: Signaling protein]]
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