2j85

B116 of Sulfolobus turreted icosahedral virus (STIV)

spinqualitylabelsall models 2j85, resolution 2.39Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2j85 is a 2 chain structure with sequence from Sulfolobus turreted icosahedral virus. This structure supersedes the now removed PDB entry 2blk. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Sulfolobus turreted icosahedral virus (STIV) infects Sulfolobus species found in the hot springs of Yellowstone National Park. Its 37 open reading frames (ORFs) generally lack sequence similarity to other genes. One exception, however, is ORF B116. While its function is unknown, orthologs are found in three additional crenarchaeal viral families. Due to the central importance of this protein family to crenarchaeal viruses, we have undertaken structural and biochemical studies of B116. The structure reveals a previously unobserved fold consisting of a five-stranded beta-sheet flanked on one side by three alpha helices. Two subunits come together to form a homodimer with a 10-stranded mixed beta-sheet, where the topology of the central strands resembles an unclosed beta-barrel. Highly conserved loops rise above the surface of the saddle-shaped protein and suggest an interaction with the major groove of DNA. The predicted B116-DNA interaction is confirmed by electrophoretic mobility shift assays. A new DNA binding protein highly conserved in diverse crenarchaeal viruses.,Larson ET, Eilers BJ, Reiter D, Ortmann AC, Young MJ, Lawrence CM Virology. 2007 Jul 5;363(2):387-96. Epub 2007 Mar 2. PMID:17336360 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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