Laccase: Difference between revisions
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== Function == | == Function == | ||
'''Laccase''' (Lac) is a multi-copper protein which uses molecular oxygen to oxidize various aromatic and non-aromatic compounds by a radical-catalyzed reaction mechanism</ref><ref>PMID:15036303</ref> | '''Laccase''' (Lac) is a multi-copper protein which uses molecular oxygen to oxidize various aromatic and non-aromatic compounds by a radical-catalyzed reaction mechanism</ref><ref>PMID:15036303</ref>. '''Laccase 2''' (Lac2) acts in lignin degradation and in detoxification of lignin products. Typically, laccases show a three cupredoxin-domain folding<ref>PMID:25586560</ref>. '''Two-domain laccase''' or small lactase have unusual resistance to inhibitors<ref>PMID:25778839</ref>. '''CotA laccase''' belongs to the multi-copper oxidase family. | ||
'''CotA laccase''' belongs to the multi-copper oxidase family. | |||
The multi-copper oxidases constitute a family of enzymes whose | The multi-copper oxidases constitute a family of enzymes whose | ||
principal members are laccase (benzenediol oxygen oxidoreductase, | principal members are laccase (benzenediol oxygen oxidoreductase, | ||
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For laccase with nitrotyrosine modification see [[Nitrotyrosine]]. | For laccase with nitrotyrosine modification see [[Nitrotyrosine]]. | ||
== Relevance == | |||
Laccase from various fungi is used in adsorption of dyes from polluted environment</ref><ref>PMID:30997348</ref>. Laccases play an important role in food industry, paper and pulp industry, textile industry, synthetic chemistry, cosmetics, soil bioremediation and biodegradation of phenolic pollutants<ref>PMID:21755038</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
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it to the trinuclear centre. | it to the trinuclear centre. | ||
==3D structures of laccase== | |||
[[Laccase 3D structures]] | [[Laccase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
==3D structures of | ==3D structures of laccase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Laccase | |||
**[[1v10]] – Lac + Cu – ''Rigidoporus lignosus''<br /> | |||
**[[2h5u]] – Lac + Cu – ''Trametes maxima''<br /> | |||
**[[2hzh]] – Lac + Cu – ''Trametes ochracea''<br /> | |||
**[[3x1b]] – Lac + Cu – ''Lentinus''<br /> | |||
**[[5anh]] – Lac + Cu – ''Basidiomycete''<br /> | |||
**[[5ehf]] – Lac + Cu – ''Antrodiella faginea''<br /> | |||
**[[4a2d]], [[4a2e]], [[4a2f]], [[4a2g]], [[4a2h]], [[5a7e]] – Lac + Cu – ''Coriolopsis gallica''<br /> | |||
**[[4jhu]], [[4jhv]] – Lac + Cu – ''Coriolopsis caperata''<br /> | |||
**[[3t6v]], [[3t6w]], [[3t6x]], [[3t6z]], [[3t71]] – Lac + Cu – ''Steccherinum ochraceum''<br /> | |||
**[[3sqr]], [[4x4k]] – BaLac + Cu – ''Botrytis aclada''<br /> | |||
**[[3v9e]] – BaLac (mutant) + Cu <br /> | |||
**[[2xuw]], [[2xvb]] – TtLac – ''Thermus thermophilus''<br /> | |||
**[[2yap]], [[5jx9]], [[5k0d]], [[5k15]], [[5k3k]], [[5k5k]], [[5k7a]], [[5k84]] – TtLac + Cu <br /> | |||
**[[2xu9]] – TtLac (mutant) + Cu <br /> | |||
**[[2yae]], [[5jrr]] – TtLac + Cu + O2 <br /> | |||
**[[2yaf]], [[2yah]], [[2yam]], [[2yao]], [[2yaq]], [[2yar]], [[5afa]] – TtLac + Cu + OH <br /> | |||
**[[2xyb]] – Lac + Cu + O2 – ''Pycnoporus cinnabarinus'' <br /> | |||
**[[3pps]] – Lac + Cu + O2 – ''Thielavia arenaria'' <br /> | |||
**[[3cg8]] – Lac + Cu + O – ''Streptomyces coelicolor'' <br /> | |||
**[[3tbb]] – Lac + Cu + O2 – ''Streptomyces viridosporus'' <br /> | |||
**[[4f7k]] – Lac – uncultured bacterium<br /> | |||
**[[5nq7]], [[5nq8]], [[5nq9]] – Lac + Cu + O2 – ''Trametes sanguinea''<br /> | |||
**[[5z1x]], [[5z22]] – Lac + Cu + O2 – ''Cerrena''<br /> | |||
*Laccase 1 | |||
**[[3qpk]] – MaLac1 + Cu – ''Melanocarpus albomyces''<br /> | |||
**[[1gw0]], [[2ih8]], [[2ih9]], [[2q9o]] – MaLac1 + Cu + O <br /> | |||
**[[3dkh]] – MaLac1 (mutant) + Cu + O2<br /> | |||
**[[3fu7]], [[3fu8]], [[3fu9]] – MaLac1 + Cu + O2 + phenol derivative<br /> | |||
**[[1hfu]] – icfLac1 + Cu – inky cap fungus<br /> | |||
**[[5ldu]] – wrfLac1 + Cu – white-rot fungus<br /> | |||
**[[6f5k]] – Lac1 + Cu + OH – ''Myceliophthora thermophila'' <br /> | |||
*Laccase 2 | |||
**[[1a65]] – icfLac2 + Cu + O <br /> | |||
**[[1gyc]], [[3fpx]], [[3kw7]], [[3pxl]] – wrfLac2 + Cu <br /> | |||
**[[3v9c]] – wrfLac2 + Cu + O2<br /> | |||
**[[1kya]] – Lac2 + Cu + arylamine – ''Trametes versicolor''<br /> | |||
**[[5e9n]], [[6rgh]] – SmLac2 + Cu – ''Steccherinum murashkinskyi''<br /> | |||
**[[5mej]], [[5mew]], [[5mhu]], [[5mhv]], [[5mhw]], [[5mhx]], [[5mhy]], [[5mhz]], [[5mi1]], [[5mi2]], [[5mia]], [[5mib]], [[5mic]], [[5mid]], [[5mie]], [[5mig]], [[6rgp]], [[6rhh]], [[6rhi]], [[6rho]], [[6rhp]], [[6rhr]], [[6rhu]], [[6rhx]], [[6ri0]], [[6ri2]], [[6ri4]], [[6ri6]], [[6ri8]], [[6rii]], [[6rik]], [[6ril]] – SmLac2 + Cu + O2<br /> | |||
*Two-domain laccase | |||
**[[2zwn]] – Lac + Cu + Cu-O-Cu – metagenomes<br /> | |||
**[[5lhl]] – SgLac + Cu + O2 – ''Streptomyces griseoflavus'' <br /> | |||
**[[5mkm]], [[5o3k]], [[5o4i]], [[5o4q]], [[6fc7]], [[6fdj]] – SgLac (mutant) + Cu + O2 + O <br /> | |||
*CotA laccase | *CotA laccase | ||
