Hydroxysteroid dehydrogenase

spinqualitylabelsall models Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP 1lwi Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Hydroxysteroid dehydrogenase (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of the carbon it is acting on. 3-α HSD catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme. 7-α HSD is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme. 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 11-β HSD converts 11-keto products like cortisone to cortisol. 17-β HSD is involved in the conversion of androstenedione to testosterone. 3-β/17-β HSD catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17. NAD and NADP are cofactors of HSD. Disease Deficiency of 17-β HSD caused by mutations are the cause of male hermaphroditism. Deficiency of 3-β HSD caused by mutations are the cause of congenital adrenal hyperplasia. Deficiency of 11-β HSD is associated with alcoholic and non-alcoholic chronic liver disease. Structural highlights The structure of 3-α HSD is that of an α/β barrel with the cofactor NADP binding site at the C-terminal of the barrel. Water molecules shown as red spheres.

3D structures of hydroxysteroid dehydrogenase

Updated on 19-May-2019

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• 3-α HSD or AKR1C2

For 3-α HSD type 2 see NAD

• • 1ral – rHSD – rat
    
  • 1fjh - CtHSD – Comamonas testosterone
    
  • 4is2 – CsHSD – Clostridium scindens
    
• 3-α HSD binary complex
  • 1lwi – rHSD + NADP
    
  • 1fk8 – CtHSD + NAD
    
  • 2fvl, 2hdj - hHSD + NADP
    
  • 2dkn - HSD + NAD – Pseudomonas
    
  • 4is3 - CsHSD + NAD
    
• 3-α HSD ternary complex
  • 1afs - rHSD + hydroxysteroid + NADP
    
  • 4jq1, 4jq2, 4jq3, 4jq4, 4jqa, 4jtq, 4jtr - hHSD + NSAID drug + NADP - human
    
• 3-α HSD type 3
  • 2hdj - hHSD + NADP
    
  • 1ihi, 1j96 - hHSD + hydroxysteroid + NADP
    
  • 1xjb - hHSD + citrate+ acetate + NADP
    
  • 4l1w - hHSD + progesterone + NADP
    
  • 4l1x - hHSD (mutant) + progesterone + NADP
    
  • 4xo6, 4xo7 – hHSD + NADP + epiandrosterone derivative
    
• 7-α HSD
  • 3gaf - HSD – Brucella melitensis
    
  • 1ahh – EcHSD + NAD – Escherichia coli
    
  • 1ahi, 1fmc – EcHSD + hydroxysteroid + NAD
• 20-α HSD or AKR1C1
  • 1q5m - raHSD + NADP – rabbit
• 20-α HSD ternary complex
  • 1mrq – hHSD + hydroxysteroid + NADP
    
  • 4yvp – hHSD + NADP + sulfonylurea derivative
    
  • 3c3u, 3nty - hHSD + inhibitor + NADP
    
  • 3gug - hHSD (mutant) + inhibitor + NADP
    
  • 1q13 - raHSD + hydroxysteroid + NADP
    
• 11-β HSD
  • 1xu7, 1xu9 - hHSD (mutant) + NADP
    
  • 2pd6 - hHSD + NAD
    
  • 1y5m - mHSD + NADP
    
  • 1xse - gpHSD catalytic domain + NADP – guinea pig
    
  • 3hb4 - hHSD + inhibitor
    
  • 3dey - hHSD + hydroxysteroid
    
  • 3dwf, 3lz6 - gpHSD catalytic domain (mutant) + NADP
    
• 11-β HSD ternary complex
  • 3g49 - gpHSD catalytic domain + inhibitor + NADP
    
  • 1y5r, 3gmd - mHSD 1 + hydroxysteroid + NADP
    
  • 4k26 - mHSD 1 + inhibitor + NADP
    
  • 4nmh - mHSD 1 (mutant) + inhibitor + NADP
    
  • 2bel - hHSD 1 + hydroxysteroid + NADP
    
  • 2irw, 2ilt, 4bb5, 4bb6 - hHSD 1 + inhibitor + NADP
    
  • 2rbe, 3byz, 3bzu, 3ch6, 3czr, 3d3e, 3d4n, 3d5q, 3ey4, 3frj, 3hfg, 3fco, 3h6k, 3oq1, 3pdj, 3tfq, 3qqp, 4c7j, 4c7k, 4p38 - hHSD 1 (mutant) + inhibitor + NADP
    
• 17-α HSD or AKR1C21
  • 2he8 – mHSD - mouse
    
  • 3fjn - mHSD (mutant)
    
  • 2p5n, 2he5, 2hej - mHSD + NADP
    
  • 2ipf - mHSD + hydroxysteroid + NADP
    
  • 2ipg, 2ipj - mHSD (mutant) + hydroxysteroid + NADP
    
  • 3cv6 - mHSD (mutant) + inhibitor + NADP
    
• 17-β HSD

For 17-β HSD type 5 or AKR1C3 see Prostaglandin F synthase

• • 1bhs, 5ics – hHSD
    
  • 1s9c - hHSD (mutant)
    
  • 3is3 – ClHSD – Cochliobolus lunatus
    
  • 3itd - ClHSD (mutant)
• 17-β HSD binary complex
  • 3qwf - ClHSD + NADP
    
  • 4fj0, 4fj1, 4fj2, 4fiz – ClHSD + dehydroxy flavonoid inhibitor
    
  • 1fdw, 1dht - hHSD (mutant) + hydroxysteroid
    
  • 1jtv, 1yb1, 3dhe, 1fds, 1iol, 3klm, 3klp, 3km0 - hHSD + hydroxysteroid
  • 1fdv - hHSD (mutant) + NAD
    
  • 1zbq, 5js6, 5jsf - hHSD + NAD
    
  • 1qyv - hHSD + NADP
    
  • 1i5r, 5l7t, 5l7w, 5l7y, 5icm, 5en4 - hHSD + inhibitor
    
• 17-β HSD ternary complex
  • 1qyw, 1qyx, 1fdt - hHSD 1 + hydroxysteroid + NADP
    
  • 1a27, 1fdu - hHSD 1 (mutant) + hydroxysteroid + NADP
    
  • 3hb5 - hHSD 1 + inhibitor + NADP
    
  • 4hfr, 4hx5, 4iju, 4ijv, 4ijw, 4k1l - hHSD 1 (mutant) + inhibitor + NADP
    
  • 5o42, 5o43, 5o6o, 5o6x, 5o6z, 5o72 - hHSD 14 + inhibitor + NAD
    
  • 5hs6 - hHSD + NAD + estrone
    
  • 4cql - hHSD 8 + carbonyl reductase + NAD
    
  • 4cqm - hHSD 8 + carbonyl reductase + NADP
    
  • 3qwi, 3qwh - ClHSD + hydroxysteroid + NADP
    
• 3-α 20-β HSD
  • 2hsd – SeHSD – Streptomyces exfoliates
    
  • 1hdc – SeHSD + inhibitor
• Carbonyl reductase/20-β HSD
  • 1n5d - HSD + NADP – pig
    
• 3-β/17-β HSD
  • 1hxh - CtHSD

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