5zt2: Difference between revisions

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'''Unreleased structure'''


The entry 5zt2 is ON HOLD  until Paper Publication
==Crystal structure of CCG DNA repeats at 1.66 angstrom resolution==
<StructureSection load='5zt2' size='340' side='right'caption='[[5zt2]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zt2]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4qno 4qno]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZT2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zt2 OCA], [http://pdbe.org/5zt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zt2 RCSB], [http://www.ebi.ac.uk/pdbsum/5zt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zt2 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
CCG triplet repeats can fold into tetraplex structures, which are associated with the expansion of (CCG)n trinucleotide sequences in certain neurological diseases. These structures are stabilized by intertwining i-motifs. However, the structural basis for tetraplex i-motif formation in CCG triplet repeats remains largely unknown. We report the first crystal structure of a CCG-repeat sequence, which shows that two dT(CCG)3 A strands can associate to form a tetraplex structure with an i-motif core containing four C:C(+) pairs flanked by two G:G homopurine base pairs as a structural motif. The tetraplex core is attached to a short parallel-stranded duplex. Each hairpin itself contains a central CCG loop in which the nucleotides are flipped out and stabilized by stacking interactions. The helical twists between adjacent cytosine residues of this structure in the i-motif core have an average value of 30 degrees , which is greater than those previously reported for i-motif structures.


Authors: Hou, M.H., Wu, P.C., Satange, R.B., Chen, Y.W.
Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats.,Chen YW, Jhan CR, Neidle S, Hou MH Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10682-6. doi: 10.1002/anie.201405637. , Epub 2014 Aug 19. PMID:25139267<ref>PMID:25139267</ref>


Description: Crystal structure of CCG DNA repeats at 1.66 angstrom resolution
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Satange, R.B]]
<div class="pdbe-citations 5zt2" style="background-color:#fffaf0;"></div>
[[Category: Hou, M.H]]
== References ==
[[Category: Chen, Y.W]]
<references/>
[[Category: Wu, P.C]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Chen, Y W]]
[[Category: Hou, M H]]
[[Category: Satange, R B]]
[[Category: Wu, P C]]
[[Category: Dna]]
[[Category: Dna structure]]
[[Category: I-motif]]
[[Category: Neurological disease]]
[[Category: Tetraplex structure]]
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