6h24: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 6h24 is ON HOLD
==X-Ray Crystal Structure of the MSBI1.176 WH1 Domain, a Replication Protein Isolated from a Multiple Sclerosis Patient==
<StructureSection load='6h24' size='340' side='right'caption='[[6h24]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6h24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphinx1.76-related_dna Sphinx1.76-related dna]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H24 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rep ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1515702 Sphinx1.76-related DNA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h24 OCA], [http://pdbe.org/6h24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h24 RCSB], [http://www.ebi.ac.uk/pdbsum/6h24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h24 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bovine meat and milk factors (BMMFs) are circular, single-stranded episomal DNAs that have been detected in bovine meat and milk products. BMMFs are thought to have roles in human malignant and degenerative diseases. BMMFs encode a replication initiator protein (Rep) that is actively transcribed and translated in human cells. In this study, a Rep WH1 domain encoded on a BMMF (MSBI1.176) isolated from a multiple sclerosis human brain sample was determined to 1.53 A resolution using X-ray crystallography. The overall structure of the MSBI1.176 WH1 domain was remarkably similar to other Rep structures, despite having a low (28%) amino-acid sequence identity. The MSBI1.176 WH1 domain contained elements common to other Reps, including five alpha-helices, five beta-strands and a hydrophobic pocket. These new findings suggest that the MSBI1.176 Rep might have comparable roles and functions to other known Reps of different origins.


Authors: Kilic, T., Popov, A.N., Hansman, G.S.
Structural analysis of a replication protein encoded by a plasmid isolated from a multiple sclerosis patient.,Kilic T, Popov AN, Burk-Korner A, Koromyslova A, Zur Hausen H, Bund T, Hansman GS Acta Crystallogr D Struct Biol. 2019 May 1;75(Pt 5):498-504. doi:, 10.1107/S2059798319003991. Epub 2019 Apr 29. PMID:31063152<ref>PMID:31063152</ref>


Description: X-Ray Crystal Structure of the MSBI1.176 WH1 Domain, a Replication Protein Isolated from a Multiple Sclerosis Patient
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Hansman, G.S]]
<div class="pdbe-citations 6h24" style="background-color:#fffaf0;"></div>
[[Category: Popov, A.N]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sphinx1 76-related dna]]
[[Category: Hansman, G S]]
[[Category: Kilic, T]]
[[Category: Kilic, T]]
[[Category: Popov, A N]]
[[Category: Msbi1 176]]
[[Category: Repa]]
[[Category: Replication]]
[[Category: Sclerosis]]
[[Category: Wh1]]
Retrieved from "https://proteopedia.org/6h24"