6oov: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6oov is ~~ON HOLD~~

==Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA==

~~Authors~~: ~~Halabelian~~, L., ~~Ravichandran~~, M., Li, Y., ~~Bountra~~, C., ~~Edwards, A~~.M.~~, Arrowsmith, C~~.H., ~~Structural Genomics Consortium~~ (~~SGC~~)

== Structural highlights ==

<table><tr><td colspan='2'>[[6oov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OOV OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OOV FirstGlance].

~~Description~~: ~~Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">HMCES, C3orf37, DC12, SRAPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

[[Category: Arrowsmith, C.H]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oov OCA], [http://pdbe.org/6oov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oov RCSB], [http://www.ebi.ac.uk/pdbsum/6oov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oov ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN]] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Human]]

[[Category: Large Structures]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Edwards, A M]]

[[Category: Halabelian, L]]

[[Category: Li, Y]]

[[Category: ~~Ravichandran~~, M]]

[[Category: Structural genomic]]

[[Category: ~~Halabelian, L~~]]

[[Category: Zeng, H]]

[[Category: ~~Edwards, A.M~~]]

[[Category: 3' overhang]]

[[Category: ~~Structural Genomics Consortium (~~Sgc)]]

[[Category: Dna binding protein]]

[[Category: ~~Bountra, C~~]]

[[Category: Dna binding protein-dna complex]]

[[Category: Dna-damage protein]]

[[Category: Dna-protein complex]]

[[Category: Hmce]]

[[Category: Sgc]]

[[Category: Srap domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6oov is ON HOLD
+==Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA==
+<StructureSection load='6oov' size='340' side='right'caption='[[6oov]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Halabelian, L., Ravichandran, M., Li, Y., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6oov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OOV FirstGlance]. <br>
-Description: Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMCES, C3orf37, DC12, SRAPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-[[Category: Arrowsmith, C.H]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oov OCA], [http://pdbe.org/6oov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oov RCSB], [http://www.ebi.ac.uk/pdbsum/6oov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oov ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN]] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: Large Structures]]
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Edwards, A M]]
+[[Category: Halabelian, L]]
 [[Category: Li, Y]]
-[[Category: Ravichandran, M]]
+[[Category: Structural genomic]]
-[[Category: Halabelian, L]]
+[[Category: Zeng, H]]
-[[Category: Edwards, A.M]]
+[[Category: 3' overhang]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Dna binding protein]]
-[[Category: Bountra, C]]
+[[Category: Dna binding protein-dna complex]]
+[[Category: Dna-damage protein]]
+[[Category: Dna-protein complex]]
+[[Category: Hmce]]
+[[Category: Sgc]]
+[[Category: Srap domain]]