5zxm: Difference between revisions
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==Crystal Structure of GyraseB N-terminal at 1.93A Resolution== | |||
<StructureSection load='5zxm' size='340' side='right'caption='[[5zxm]], [[Resolution|resolution]] 1.94Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5zxm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZXM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxm OCA], [http://pdbe.org/5zxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxm RCSB], [http://www.ebi.ac.uk/pdbsum/5zxm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/A0A1Z3Q9E9_SALET A0A1Z3Q9E9_SALET]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Ethayathulla, A S]] | |||
[[Category: Gupta, D]] | [[Category: Gupta, D]] | ||
[[Category: Kaur, P]] | [[Category: Kaur, P]] | ||
[[Category: Sachdeva, E]] | [[Category: Sachdeva, E]] | ||
[[Category: Sharma, S]] | |||
[[Category: Singh, T P]] | |||
[[Category: Tiwari, P]] | |||
[[Category: Atp binding domain]] | |||
[[Category: Gyrb-ntd]] | |||
[[Category: Isomerase]] | |||
[[Category: Topoisomerase]] | |||
Revision as of 06:42, 23 May 2019
Crystal Structure of GyraseB N-terminal at 1.93A Resolution
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