6nk3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6nk3 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of murine Mxra8 ectodomain==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6nk3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NK3 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nk6|6nk6]], [[6nk7|6nk7]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nk3 OCA], [http://pdbe.org/6nk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nk3 RCSB], [http://www.ebi.ac.uk/pdbsum/6nk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nk3 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MXRA8_MOUSE MXRA8_MOUSE]] Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461).[UniProtKB:Q9BRK3]<ref>PMID:14603461</ref> <ref>PMID:18366072</ref> <ref>PMID:22492581</ref> <ref>PMID:29702220</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Structural genomic]]

[[Category: Fremont, D H]]

[[Category: Kim, A S]]

[[Category: Nelson, C A]]

[[Category: Cell invasion]]

[[Category: Chikungunya]]

[[Category: Csgid]]

[[Category: Immunoglobulin-like]]

[[Category: Virus receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6nk3 is ON HOLD  until Paper Publication
+==Crystal structure of murine Mxra8 ectodomain==
+<StructureSection load='6nk3' size='340' side='right'caption='[[6nk3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nk3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NK3 FirstGlance]. <br>
-Description:
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nk6|6nk6]], [[6nk7|6nk7]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nk3 OCA], [http://pdbe.org/6nk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nk3 RCSB], [http://www.ebi.ac.uk/pdbsum/6nk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nk3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MXRA8_MOUSE MXRA8_MOUSE]] Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461).[UniProtKB:Q9BRK3]<ref>PMID:14603461</ref> <ref>PMID:18366072</ref> <ref>PMID:22492581</ref> <ref>PMID:29702220</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Structural genomic]]
+[[Category: Fremont, D H]]
+[[Category: Kim, A S]]
+[[Category: Nelson, C A]]
+[[Category: Cell invasion]]
+[[Category: Chikungunya]]
+[[Category: Csgid]]
+[[Category: Immunoglobulin-like]]
+[[Category: Virus receptor]]