6nk7: Difference between revisions
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==Electron Cryo-Microscopy of Chikungunya in Complex with Mouse Mxra8 Receptor== | |||
<StructureSection load='6nk7' size='340' side='right'caption='[[6nk7]], [[Resolution|resolution]] 4.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nk7]] is a 17 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NK7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Togavirin Togavirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.90 3.4.21.90] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nk7 OCA], [http://pdbe.org/6nk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nk7 RCSB], [http://www.ebi.ac.uk/pdbsum/6nk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nk7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MXRA8_MOUSE MXRA8_MOUSE]] Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461).[UniProtKB:Q9BRK3]<ref>PMID:14603461</ref> <ref>PMID:18366072</ref> <ref>PMID:22492581</ref> <ref>PMID:29702220</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Togavirin]] | |||
[[Category: Basore, K]] | |||
[[Category: Structural genomic]] | |||
[[Category: Fremont, D H]] | |||
[[Category: Kim, A S]] | |||
[[Category: Nelson, C A]] | |||
[[Category: Chikungunya]] | |||
[[Category: Csgid]] | |||
[[Category: Mxra8]] | |||
[[Category: Viral receptor]] | |||
[[Category: Virus]] | |||
Revision as of 06:53, 23 May 2019
Electron Cryo-Microscopy of Chikungunya in Complex with Mouse Mxra8 Receptor
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