6o7g: Difference between revisions
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The entry | ==Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide== | ||
<StructureSection load='6o7g' size='340' side='right'caption='[[6o7g]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6o7g]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O7G FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o7g OCA], [http://pdbe.org/6o7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o7g RCSB], [http://www.ebi.ac.uk/pdbsum/6o7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o7g ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN]] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.<ref>PMID:16603732</ref> <ref>PMID:17500065</ref> <ref>PMID:17851529</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Histone-lysine N-methyltransferase]] | |||
[[Category: Large Structures]] | |||
[[Category: Kutateladze, T G]] | |||
[[Category: Zhang, Y]] | |||
[[Category: Acetylation]] | |||
[[Category: Chromatin]] | |||
[[Category: H4k16ac]] | |||
[[Category: Histone]] | |||
[[Category: Mll4]] | |||
[[Category: Mof]] | |||
[[Category: Phd finger]] | |||
[[Category: Transcription]] | |||
Revision as of 06:55, 23 May 2019
Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide
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