6edc: Difference between revisions
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==hcGAS-16bp dsDNA complex== | |||
<StructureSection load='6edc' size='340' side='right'caption='[[6edc]], [[Resolution|resolution]] 2.71Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6edc]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EDC FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6edc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6edc OCA], [http://pdbe.org/6edc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6edc RCSB], [http://www.ebi.ac.uk/pdbsum/6edc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6edc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cyclic GMP-AMP synthase]] | |||
[[Category: Large Structures]] | |||
[[Category: Adura, C]] | |||
[[Category: Glickman, J F]] | |||
[[Category: Lama, L]] | |||
[[Category: Patel, D J]] | |||
[[Category: Tuschl, T]] | |||
[[Category: Xie, W]] | |||
[[Category: Human cgas dna complex]] | |||
[[Category: Transferase-dna complex]] | |||
