6mh2: Difference between revisions
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==Structure of Herceptin Fab without antigen== | |||
<StructureSection load='6mh2' size='340' side='right'caption='[[6mh2]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mh2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MH2 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mh2 OCA], [http://pdbe.org/6mh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mh2 RCSB], [http://www.ebi.ac.uk/pdbsum/6mh2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mh2 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We developed a repertoire approach to generate human antibody bispecifics. Using phage display selection of antibody heavy chains in the presence of a competitor light chain and providing a cognate light chain with an affinity handle, we identified mutations that prevent heavy/light chain mispairing. The strategy allows for the selection of human antibody chains that autonomously assemble into bispecifics. | |||
Human Antibody Bispecifics through Phage Display Selection.,Luthra A, Langley DB, Schofield P, Jackson J, Abdelatti M, Rouet R, Nevoltris D, Mazigi O, Crossett B, Christie M, Christ D Biochemistry. 2019 Apr 2;58(13):1701-1704. doi: 10.1021/acs.biochem.9b00037. Epub, 2019 Mar 22. PMID:30900875<ref>PMID:30900875</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6mh2" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Christ, D]] | |||
[[Category: Christie, M]] | |||
[[Category: Langley, D B]] | |||
[[Category: Luthra, A]] | |||
[[Category: Antibody]] | |||
[[Category: Fab fragment]] | |||
[[Category: Herceptin]] | |||
[[Category: Immune system]] | |||
Revision as of 06:13, 29 May 2019
Structure of Herceptin Fab without antigen
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