6mju: Difference between revisions
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==human cGAS catalytic domain bound with the inhibitor G108== | |||
<StructureSection load='6mju' size='340' side='right'caption='[[6mju]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mju]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJU FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JUM:1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mju OCA], [http://pdbe.org/6mju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mju RCSB], [http://www.ebi.ac.uk/pdbsum/6mju PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mju ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cyclic GMP-AMP synthase]] | |||
[[Category: Large Structures]] | |||
[[Category: Adura, C]] | |||
[[Category: Aida, J]] | |||
[[Category: Asano, Y]] | |||
[[Category: Gao, P]] | |||
[[Category: Glickman, J F]] | |||
[[Category: Gogakos, T]] | |||
[[Category: Hashizume, S]] | |||
[[Category: Imaeda, T]] | |||
[[Category: Jennings, A J]] | |||
[[Category: Kamei, T]] | |||
[[Category: Kuroita, T]] | |||
[[Category: Kuryavyi, V]] | |||
[[Category: Lama, L]] | |||
[[Category: Meinke, P]] | |||
[[Category: Michinom, M]] | |||
[[Category: Miller, M]] | |||
[[Category: Okamoto, R]] | |||
[[Category: Patel, D J]] | |||
[[Category: Ramos-Espiritu, L]] | |||
[[Category: Stamford, A]] | |||
[[Category: Steinberg, J I]] | |||
[[Category: Tomita, D]] | |||
[[Category: Tuschl, T]] | |||
[[Category: Xie, W]] | |||
[[Category: Dna sensor]] | |||
[[Category: Human cga]] | |||
[[Category: Immune system]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 06:13, 29 May 2019
human cGAS catalytic domain bound with the inhibitor G108
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Cyclic GMP-AMP synthase
- Large Structures
- Adura, C
- Aida, J
- Asano, Y
- Gao, P
- Glickman, J F
- Gogakos, T
- Hashizume, S
- Imaeda, T
- Jennings, A J
- Kamei, T
- Kuroita, T
- Kuryavyi, V
- Lama, L
- Meinke, P
- Michinom, M
- Miller, M
- Okamoto, R
- Patel, D J
- Ramos-Espiritu, L
- Stamford, A
- Steinberg, J I
- Tomita, D
- Tuschl, T
- Xie, W
- Dna sensor
- Human cga
- Immune system
- Transferase-transferase inhibitor complex
