6ny0: Difference between revisions
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==Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor== | |||
<StructureSection load='6ny0' size='340' side='right'caption='[[6ny0]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ny0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NY0 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LBA:2-(4-{3-[4-(6-carboxy-1H-benzimidazol-2-yl)phenoxy]-2-hydroxypropoxy}phenyl)-1H-benzimidazole-5-carboxylic+acid'>LBA</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> | ||
[[Category: Yachnin, B | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ny0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ny0 OCA], [http://pdbe.org/6ny0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ny0 RCSB], [http://www.ebi.ac.uk/pdbsum/6ny0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ny0 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/DYR21_ECOLX DYR21_ECOLX]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dihydrofolate reductase]] | |||
[[Category: Large Structures]] | |||
[[Category: Berghuis, A M]] | |||
[[Category: Yachnin, B J]] | |||
[[Category: Antibiotic]] | |||
[[Category: Antibiotic resistance]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: R67 dhfr]] | |||
[[Category: Selective inhibitor]] | |||
[[Category: Sh3-like barrel]] | |||
Revision as of 06:15, 29 May 2019
Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor
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