6o2x: Difference between revisions
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==Structure of cruzain bound to MMTS inhibitor== | |||
<StructureSection load='6o2x' size='340' side='right'caption='[[6o2x]], [[Resolution|resolution]] 1.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6o2x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O2X FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o2x OCA], [http://pdbe.org/6o2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o2x RCSB], [http://www.ebi.ac.uk/pdbsum/6o2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o2x ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cruzipain]] | |||
[[Category: Large Structures]] | |||
[[Category: Brandstetter, H]] | |||
[[Category: Dall, E]] | [[Category: Dall, E]] | ||
[[Category: | [[Category: Ferreira, R S]] | ||
[[Category: Silva, E | [[Category: Silva, E B]] | ||
[[Category: | [[Category: Autocatalytic cleavage]] | ||
[[Category: Cysteine protease]] | |||
[[Category: Hydrolase]] | |||
[[Category: Protease]] | |||
