6o66: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6o66 is ~~ON HOLD until Paper Publication~~

==Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B==

~~Authors~~: ~~Gerlits~~, O., ~~Kovalevsky~~, A., ~~Radic~~, Z.

== Structural highlights ==

<table><tr><td colspan='2'>[[6o66]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O66 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O66 FirstGlance].

~~Description~~: ~~Structure~~ of ~~VX-phosphonylated hAChE~~ in ~~complex with oxime reactivator RS-170B~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LND:4-carbamoyl-1-(3-{2-[(E)-(hydroxyimino)methyl]-1H-imidazol-1-yl}propyl)pyridin-1-ium'>LND</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=SVX:O-[(R)-ETHOXY(METHYL)PHOSPHORYL]-L-SERINE'>SVX</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6o5r|6o5r]], [[6o5s|6o5s]], [[6o5v|6o5v]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o66 OCA], [http://pdbe.org/6o66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o66 RCSB], [http://www.ebi.ac.uk/pdbsum/6o66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o66 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Acetylcholinesterase]]

[[Category: Large Structures]]

[[Category: Gerlits, O]]

[[Category: Kovalevsky, A]]

[[Category: Radic, Z]]

[[Category: ~~Kovalevsky, A~~]]

[[Category: Human acetylcholinesterase]]

[[Category: Hydrolase]]

[[Category: Imidazole-based oxime]]

[[Category: Oxime reactivator]]

[[Category: Rs-170b]]

[[Category: Vx-hache]]

[[Category: Vx-phosphonylated]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6o66 is ON HOLD  until Paper Publication
+==Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B==
+<StructureSection load='6o66' size='340' side='right'caption='[[6o66]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-Authors: Gerlits, O., Kovalevsky, A., Radic, Z.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6o66]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O66 FirstGlance]. <br>
-Description: Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LND:4-carbamoyl-1-(3-{2-[(E)-(hydroxyimino)methyl]-1H-imidazol-1-yl}propyl)pyridin-1-ium'>LND</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SVX:O-[(R)-ETHOXY(METHYL)PHOSPHORYL]-L-SERINE'>SVX</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6o5r|6o5r]], [[6o5s|6o5s]], [[6o5v|6o5v]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o66 OCA], [http://pdbe.org/6o66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o66 RCSB], [http://www.ebi.ac.uk/pdbsum/6o66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o66 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Acetylcholinesterase]]
+[[Category: Large Structures]]
 [[Category: Gerlits, O]]
+[[Category: Kovalevsky, A]]
 [[Category: Radic, Z]]
-[[Category: Kovalevsky, A]]
+[[Category: Human acetylcholinesterase]]
+[[Category: Hydrolase]]
+[[Category: Imidazole-based oxime]]
+[[Category: Oxime reactivator]]
+[[Category: Rs-170b]]
+[[Category: Vx-hache]]
+[[Category: Vx-phosphonylated]]