6bnm: Difference between revisions
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==Crystal Structure of the P-Rex2 PH domain== | |||
<StructureSection load='6bnm' size='340' side='right'caption='[[6bnm]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BNM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
[[Category: | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PREX2, DEPDC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bnm OCA], [http://pdbe.org/6bnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bnm RCSB], [http://www.ebi.ac.uk/pdbsum/6bnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bnm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PREX2_HUMAN PREX2_HUMAN]] Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.<ref>PMID:15304342</ref> <ref>PMID:15304343</ref> <ref>PMID:15897194</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Cash, J N]] | |||
[[Category: Sharma, P V]] | |||
[[Category: Tesmer, J J.G]] | |||
[[Category: Beta sandwich]] | |||
[[Category: Lipid binding protein]] | |||
[[Category: Phosphatidylinositol-binding]] | |||
[[Category: Pleckstrin homology domain]] | |||
Revision as of 22:59, 5 June 2019
Crystal Structure of the P-Rex2 PH domain
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