6c59: Difference between revisions
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==Chimeric Pol kappa RIR Rev1 C-terminal domain== | |||
<StructureSection load='6c59' size='340' side='right'caption='[[6c59]], [[Resolution|resolution]] 2.03Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6c59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C59 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c59 OCA], [http://pdbe.org/6c59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c59 RCSB], [http://www.ebi.ac.uk/pdbsum/6c59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c59 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/POLK_MOUSE POLK_MOUSE]] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).<ref>PMID:12432099</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Wojtaszek, J L]] | |||
[[Category: Zhou, P]] | |||
[[Category: Dna damage tolerance]] | |||
[[Category: Replication]] | |||
[[Category: Translesion synthesis]] | |||
Revision as of 05:29, 12 June 2019
Chimeric Pol kappa RIR Rev1 C-terminal domain
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