6c8c: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6c8c is ~~ON HOLD~~ ~~until Paper Publication~~

==Chimeric Pol kappa RIR Rev1 C-terminal domain in complex with JHRE06==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6c8c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C8C FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EQ7:8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one'>EQ7</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c8c OCA], [http://pdbe.org/6c8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c8c RCSB], [http://www.ebi.ac.uk/pdbsum/6c8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c8c ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/POLK_MOUSE POLK_MOUSE]] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).<ref>PMID:12432099</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Najeeb, J]]

[[Category: Zhou, P]]

[[Category: Dna damage tolerance]]

[[Category: Replication]]

[[Category: Rev1]]

[[Category: Translesion synthesis]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6c8c is ON HOLD  until Paper Publication
+==Chimeric Pol kappa RIR Rev1 C-terminal domain in complex with JHRE06==
+<StructureSection load='6c8c' size='340' side='right'caption='[[6c8c]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6c8c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C8C FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EQ7:8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one'>EQ7</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c8c OCA], [http://pdbe.org/6c8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c8c RCSB], [http://www.ebi.ac.uk/pdbsum/6c8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c8c ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/POLK_MOUSE POLK_MOUSE]] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).<ref>PMID:12432099</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Najeeb, J]]
+[[Category: Zhou, P]]
+[[Category: Dna damage tolerance]]
+[[Category: Replication]]
+[[Category: Rev1]]
+[[Category: Translesion synthesis]]