6nz0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6nz0 is ~~ON HOLD~~ ~~until Paper Publication~~

==Cryo-EM structure of AAV-2 in complex with AAVR PKD domains 1 and 2==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6nz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NZ0 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nz0 OCA], [http://pdbe.org/6nz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nz0 RCSB], [http://www.ebi.ac.uk/pdbsum/6nz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nz0 ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/K319L_HUMAN K319L_HUMAN]] Systemic lupus erythematosus;Limited cutaneous systemic sclerosis.

== Function ==

[[http://www.uniprot.org/uniprot/K319L_HUMAN K319L_HUMAN]] Possible role in axon guidance through interaction with RTN4R.<ref>PMID:20697954</ref> [[http://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S]] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Chapman, M S]]

[[Category: Davulcu, O]]

[[Category: Meyer, N L]]

[[Category: Xie, Q]]

[[Category: Yoshioka, C]]

[[Category: Aav]]

[[Category: Aavr]]

[[Category: Coreceptor]]

[[Category: Kiaa0319l]]

[[Category: Parvovirus]]

[[Category: Pkd]]

[[Category: Receptor]]

[[Category: Virus]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6nz0 is ON HOLD  until Paper Publication
+==Cryo-EM structure of AAV-2 in complex with AAVR PKD domains 1 and 2==
+<StructureSection load='6nz0' size='340' side='right'caption='[[6nz0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NZ0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nz0 OCA], [http://pdbe.org/6nz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nz0 RCSB], [http://www.ebi.ac.uk/pdbsum/6nz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nz0 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/K319L_HUMAN K319L_HUMAN]] Systemic lupus erythematosus;Limited cutaneous systemic sclerosis.
+== Function ==
+[[http://www.uniprot.org/uniprot/K319L_HUMAN K319L_HUMAN]] Possible role in axon guidance through interaction with RTN4R.<ref>PMID:20697954</ref>  [[http://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S]] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Chapman, M S]]
+[[Category: Davulcu, O]]
+[[Category: Meyer, N L]]
+[[Category: Xie, Q]]
+[[Category: Yoshioka, C]]
+[[Category: Aav]]
+[[Category: Aavr]]
+[[Category: Coreceptor]]
+[[Category: Kiaa0319l]]
+[[Category: Parvovirus]]
+[[Category: Pkd]]
+[[Category: Receptor]]
+[[Category: Virus]]