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'''Unreleased structure'''


The entry 6qgj is ON HOLD  until Paper Publication
==Structure of human Bcl-2 in complex with fragment/ABT-263 hybrid==
 
<StructureSection load='6qgj' size='340' side='right'caption='[[6qgj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6qgj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QGJ FirstGlance]. <br>
Description: Structure of human Bcl-2 in complex with fragment/ABT-263 hybrid
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J1T:4-[4-[(1~{R})-1-(6-methoxy-1,3-benzodioxol-5-yl)-2-pyrrolidin-1-yl-ethyl]phenyl]-~{N}-[4-[[(2~{R})-4-morpholin-4-yl-1-phenylsulfanyl-butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonyl-benzamide'>J1T</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qg8|6qg8]], [[6qgg|6qgg]], [[6qgh|6qgh]]</td></tr>
[[Category: Pedder, C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qgj OCA], [http://pdbe.org/6qgj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qgj RCSB], [http://www.ebi.ac.uk/pdbsum/6qgj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qgj ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.  
== Function ==
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Casara, P]]
[[Category: Chen, I]]
[[Category: Chen, I]]
[[Category: Williamson, D.S]]
[[Category: Smith, J]]
[[Category: Le Diguarher, T]]
[[Category: Matassova, N]]
[[Category: Davidson, J]]
[[Category: Davidson, J]]
[[Category: Wang, Y]]
[[Category: Roughley, S]]
[[Category: Walmsley, C]]
[[Category: Graham, C.J]]
[[Category: Hubbard, R.E]]
[[Category: Davis, B]]
[[Category: Davis, B]]
[[Category: Diguarher, T Le]]
[[Category: Dokurno, P]]
[[Category: Geneste, O]]
[[Category: Graham, C J]]
[[Category: Harris, R]]
[[Category: Hickman, J]]
[[Category: Hickman, J]]
[[Category: Hubbard, R E]]
[[Category: Jordan, A M]]
[[Category: Kotschy, A]]
[[Category: Matassova, N]]
[[Category: Murray, J]]
[[Category: Pedder, C]]
[[Category: Ray, S]]
[[Category: Roughley, S]]
[[Category: Smith, J]]
[[Category: Stark, J]]
[[Category: Stark, J]]
[[Category: Walmsley, C]]
[[Category: Wang, Y]]
[[Category: Whitehead, N]]
[[Category: Whitehead, N]]
[[Category: Jordan, A.M]]
[[Category: Williamson, D S]]
[[Category: Harris, R]]
[[Category: Abt-763]]
[[Category: Murray, J]]
[[Category: Apoptosis]]
[[Category: Dokurno, P]]
[[Category: Bcl2]]
[[Category: Kotschy, A]]
[[Category: Drug design]]
[[Category: Casara, P]]
[[Category: Geneste, O]]
[[Category: Ray, S]]
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