Nanog: Difference between revisions

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m Addition of dna binding information
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The struture of Nanog consists in 3 alpha helices linked to  each other by loops. The so called alpha-helix1 and alpha-helix 3 play a role into binding of the protein to DNA. The alpha-helix1, localized in the N-terminal arm, binds to DNA through minor grooves, whereas alpha-helix3 binds major grooves in DNA and is considered the recognition helix, due to it´s extensive DNA contact sufarce. Alpha helices 1 and 2 are arrenged as antiparallel to each other in the terciary structure, while positioning alpha-Helix3 in a favorable way to bind to the major grooves of the DNA helical structure.
The struture of Nanog consists in 3 alpha helices linked to  each other by loops. The so called alpha-helix1 and alpha-helix 3 play a role into binding of the protein to DNA. The alpha-helix1, localized in the N-terminal arm, binds to DNA through minor grooves, whereas alpha-helix3 binds major grooves in DNA and is considered the recognition helix, due to it´s extensive DNA contact sufarce. Alpha helices 1 and 2 are arrenged as antiparallel to each other in the terciary structure, while positioning alpha-Helix3 in a favorable way to bind to the major grooves of the DNA helical structure.


This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.


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