Nanog: Difference between revisions
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== DNA binding == | == DNA binding == | ||
Helix α3 (the so-called recognition helix) is inserted into the major groove of the DNA and forms an extensive DNA contact interface. The region upstream of helix α1 (HD residues 1–10) is referred to as the N-terminal arm and contributes to DNA binding through minor groove contacts. It was shown that in the absence and presence of DNA, the helical core of the HD constitutes a largely rigid entity that is not subjected to major structural changes upon binding to DNA. Pronounced flexibility is restricted to the N-terminal arm that becomes ordered after binding to the DNA's minor groove.[11][12] | Helix α3 (the so-called recognition helix) is inserted into the major groove of the DNA and forms an extensive DNA contact interface. The region upstream of helix α1 (HD residues 1–10) is referred to as the N-terminal arm and contributes to DNA binding through minor groove contacts. It was shown that in the absence and presence of DNA, the helical core of the HD constitutes a largely rigid entity that is not subjected to major structural changes upon binding to DNA. Pronounced flexibility is restricted to the N-terminal arm that becomes ordered after binding to the DNA's minor groove.[11][12] | ||
[[Image:Nanog-homeobox-modelo.png]] | |||
== Function == | == Function == | ||
