Parkin: Difference between revisions

Line 1:

Parkin is a protein of the RBR protein family.

Parkin is a pleiotrpic protein protein of the RBR protein family that acts as an E3 ubiquitin ligase and as a transcription factor. It is encoded by the PARK2 gene, located in the human chromosome 6. Parkin is expressed naturally in an autoinhibited state and becomes active upon phosphorylation by the Pink1 protein (PTEN-induced kinase 1).

== Function ==

Parkin is an E3 ubiquitin ligase involved in mitophagy via the Pink1-Parkin pathway. Pink1 is a kinase that phosphorilates Parkin's Ubl domain at Ser65 residue, changing its conformation and allowing it to exert its ubiquitin ligase function. Parkin can also act as a transcription factor, downregulating, for instance, the expression of p53 and PS2, and upregulating the expression of PS1.

Parkin is an E3 ubiquitin ligase involved in mitophagy via the Pink1-Parkin pathway. Pink1 is a kinase that phosphorilates Parkin's Ubl domain at Ser65 residue, changing its conformation and allowing it to exert its ubiquitin ligase function. Parkin can also act as a transcription factor, downregulating, for instance, the expression of p53 and PS2, and upregulating the expression of PS1. Besides mitophagy, parkin is known to ubiquitinate various substrates. As of 2013, about two dozen parkin substrates had been identified (Duplan '''et al'''., 2013).

== Disease ==

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
 <StructureSection load='5c1z' size='340' side='right' caption='Parkin (PDB code: 5c1z)' scene='81/817545/Rainbow/1'>
-Parkin is a protein of the RBR protein family.
+Parkin is a pleiotrpic protein protein of the RBR protein family that acts as an E3 ubiquitin ligase and as a transcription factor. It is encoded by the PARK2 gene, located in the human chromosome 6. Parkin is expressed naturally in an autoinhibited state and becomes active upon phosphorylation by the Pink1 protein (PTEN-induced kinase 1).
 == Function ==
-Parkin is an E3 ubiquitin ligase involved in mitophagy via the Pink1-Parkin pathway. Pink1 is a kinase that phosphorilates Parkin's Ubl domain at Ser65 residue, changing its conformation and allowing it to exert its ubiquitin ligase function. Parkin can also act as a transcription factor, downregulating, for instance, the expression of p53 and PS2, and upregulating the expression of PS1.
+Parkin is an E3 ubiquitin ligase involved in mitophagy via the Pink1-Parkin pathway. Pink1 is a kinase that phosphorilates Parkin's Ubl domain at Ser65 residue, changing its conformation and allowing it to exert its ubiquitin ligase function. Parkin can also act as a transcription factor, downregulating, for instance, the expression of p53 and PS2, and upregulating the expression of PS1. Besides mitophagy, parkin is known to ubiquitinate various substrates. As of 2013, about two dozen parkin substrates had been identified (Duplan '''et al'''., 2013).
 == Disease ==