Parkin: Difference between revisions
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== Function == | == Function == | ||
Parkin is an E3 ubiquitin ligase involved in mitophagy via the Pink1-Parkin pathway. Pink1 is a kinase that phosphorilates Parkin's Ubl domain at Ser65 residue, changing its conformation and allowing it to exert its ubiquitin ligase function. Parkin can also act as a transcription factor, downregulating, for instance, the expression of p53 and PS2, and upregulating the expression of PS1. Besides mitochondria, parkin is known to ubiquitinate various substrates. As of 2013, about two dozen parkin substrates had been identified | Parkin is an E3 ubiquitin ligase involved in mitophagy via the Pink1-Parkin pathway. Pink1 is a kinase that phosphorilates Parkin's Ubl domain at Ser65 residue, changing its conformation and allowing it to exert its ubiquitin ligase function. Parkin can also act as a transcription factor, downregulating, for instance, the expression of p53 and PS2, and upregulating the expression of PS1. Besides mitochondria, parkin is known to ubiquitinate various substrates. As of 2013, about two dozen parkin substrates had been identified[[1]] (Duplan ''et al''., 2013. | ||
== Disease == | == Disease == | ||
