6duv: Difference between revisions
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==Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor== | |||
<StructureSection load='6duv' size='340' side='right'caption='[[6duv]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6duv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DUV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0S6:METHYL+[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL]ACETATE'>0S6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6duv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6duv OCA], [http://pdbe.org/6duv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6duv RCSB], [http://www.ebi.ac.uk/pdbsum/6duv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6duv ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Babault, N]] | [[Category: Babault, N]] | ||
[[Category: Zhou, M | [[Category: Zhou, M M]] | ||
[[Category: Protein binding]] | |||
[[Category: Protein binding-inhibitor complex]] | |||
[[Category: Protein-small molecule inhibitor complex]] | |||
Revision as of 06:44, 26 June 2019
Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor
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