6f86: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6f86 is ON HOLD until Paper Publication~~

==Crystal Structure of E. coli GyraseB 24kDa in complex with 4-(4-bromo-1H-pyrazol-1-yl)-6-[(ethylcarbamoyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide==

~~Authors: Narramore, S.K., Stevenson, C.E.M., Lawson, D.M., Maxwell, A., Fishwick, C.W.G.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6f86]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F86 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F86 FirstGlance].

~~Description:~~ Crystal Structure of E. coli GyraseB 24kDa in complex with 4-(4-bromo-1H-pyrazol-1-yl)-6-[(ethylcarbamoyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CWW:4-(4-bromanylpyrazol-1-yl)-6-(ethylcarbamoylamino)-~{N}-pyridin-3-yl-pyridine-3-carboxamide'>CWW</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </td></tr>

[[Category: ~~Narramore~~, S.K]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f86 OCA], [http://pdbe.org/6f86 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f86 RCSB], [http://www.ebi.ac.uk/pdbsum/6f86 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f86 ProSAT]</td></tr>

[[Category: ~~Stevenson~~, ~~C.E.~~M]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GYRB_ECO57 GYRB_ECO57]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Fishwick, C W.G]]

[[Category: Lawson, D M]]

[[Category: Maxwell, A]]

[[Category: ~~Fishwick~~, ~~C.W.G~~]]

[[Category: Narramore, S K]]

[[Category: ~~Lawson~~, D.M]]

[[Category: Stevenson, C E.M]]

[[Category: Binding site]]

[[Category: Dna gyrase]]

[[Category: Inhibitor]]

[[Category: Isomerase]]

[[Category: Pyridine-3-carboxamide]]

[[Category: Topoisomerase iv]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6f86 is ON HOLD  until Paper Publication
+==Crystal Structure of E. coli GyraseB 24kDa in complex with 4-(4-bromo-1H-pyrazol-1-yl)-6-[(ethylcarbamoyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide==
+<StructureSection load='6f86' size='340' side='right'caption='[[6f86]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors: Narramore, S.K., Stevenson, C.E.M., Lawson, D.M., Maxwell, A., Fishwick, C.W.G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6f86]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F86 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F86 FirstGlance]. <br>
-Description: Crystal Structure of E. coli GyraseB 24kDa in complex with 4-(4-bromo-1H-pyrazol-1-yl)-6-[(ethylcarbamoyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CWW:4-(4-bromanylpyrazol-1-yl)-6-(ethylcarbamoylamino)-~{N}-pyridin-3-yl-pyridine-3-carboxamide'>CWW</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
-[[Category: Narramore, S.K]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f86 OCA], [http://pdbe.org/6f86 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f86 RCSB], [http://www.ebi.ac.uk/pdbsum/6f86 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f86 ProSAT]</span></td></tr>
-[[Category: Stevenson, C.E.M]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GYRB_ECO57 GYRB_ECO57]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Fishwick, C W.G]]
+[[Category: Lawson, D M]]
 [[Category: Maxwell, A]]
-[[Category: Fishwick, C.W.G]]
+[[Category: Narramore, S K]]
-[[Category: Lawson, D.M]]
+[[Category: Stevenson, C E.M]]
+[[Category: Binding site]]
+[[Category: Dna gyrase]]
+[[Category: Inhibitor]]
+[[Category: Isomerase]]
+[[Category: Pyridine-3-carboxamide]]
+[[Category: Topoisomerase iv]]