Farnesyltransferase: Difference between revisions
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<StructureSection load='' size='350' side='right' scene='48/485616/Cv/2' caption=' Farnesyltransferase α subunit (cyan) and β subunit (green) complex with farnesyl diphosphate (FPP) analog, Zn+2 ion (grey), sulfonic acid derivative and CAAX peptide (PDB code [[3q75]]) '> | <StructureSection load='' size='350' side='right' scene='48/485616/Cv/2' caption=' Farnesyltransferase α subunit (cyan) and β subunit (green) complex with farnesyl diphosphate (FPP) analog, Zn+2 ion (grey), sulfonic acid derivative and CAAX peptide (PDB code [[3q75]]) '> | ||
== Function == | |||
'''Farnesyltransferase''' (FTase) is part of the prenyltransferase group. FTase modifies proteins by adding farnesyl diphosphate (FPP) – an isoprenoid lipid – to a cysteine in a CAAX motif near the C terminal. This addition forms a thioether linkage, makes the protein more hydrophobic and associates it with the membrane. Farnesylated proteins – like those of the Ras family - are involved in cellular signaling<ref>PMID:15451670</ref> | '''Farnesyltransferase''' (FTase) is part of the prenyltransferase group. FTase modifies proteins by adding farnesyl diphosphate (FPP) – an isoprenoid lipid – to a cysteine in a CAAX motif near the C terminal. This addition forms a thioether linkage, makes the protein more hydrophobic and associates it with the membrane. Farnesylated proteins – like those of the Ras family - are involved in cellular signaling<ref>PMID:15451670</ref>. | ||
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== Relevance == | == Relevance == | ||
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FTase are composed of 2 subunits. <scene name='48/485616/Cv/11'>α subunit</scene> is in cyan, <scene name='48/485616/Cv/12'>β subunit</scene> is in green. <scene name='48/485616/Cv/13'>CAAX peptide and ligands</scene>. The <scene name='48/485616/Cv/14'>CAAX motif and β subunit coordinate with the Zn+2 ion</scene> and the <scene name='48/485616/Cv/15'>FPP predominantly coordinates with the β subunit</scene><ref>PMID:21816822</ref>. Water molecules are shown as red spheres. | FTase are composed of 2 subunits. <scene name='48/485616/Cv/11'>α subunit</scene> is in cyan, <scene name='48/485616/Cv/12'>β subunit</scene> is in green. <scene name='48/485616/Cv/13'>CAAX peptide and ligands</scene>. The <scene name='48/485616/Cv/14'>CAAX motif and β subunit coordinate with the Zn+2 ion</scene> and the <scene name='48/485616/Cv/15'>FPP predominantly coordinates with the β subunit</scene><ref>PMID:21816822</ref>. Water molecules are shown as red spheres. | ||
==3D structures of farnesyltransferase== | |||
[[Farnesyltransferase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
==3D structures of farnesyltransferase== | ==3D structures of farnesyltransferase== | ||
