Filamin: Difference between revisions
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<StructureSection load='2wa5' size='350' side='right' scene='' caption='Human Filamin B actin-binding domain complex with sulfate and carbonate (PDB code [[2wa5]]) '> | <StructureSection load='2wa5' size='350' side='right' scene='' caption='Human Filamin B actin-binding domain complex with sulfate and carbonate (PDB code [[2wa5]]) '> | ||
__TOC__ | |||
== Function == | == Function == | ||
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Mutations in FLNA cause frontometaphyseal dysplasia, intestinal pseudo-obstruction, Melnick-Needles syndrome, otopalatodigital syndrome and periventricular heterotopia. Mutations in FLNAB cause boomerang dysplasia<ref>PMID:25614868</ref>. | Mutations in FLNA cause frontometaphyseal dysplasia, intestinal pseudo-obstruction, Melnick-Needles syndrome, otopalatodigital syndrome and periventricular heterotopia. Mutations in FLNAB cause boomerang dysplasia<ref>PMID:25614868</ref>. | ||
==3D structures of filamin== | |||
[[Filamin 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
==3D structures of filamin== | ==3D structures of filamin== | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
* Filamin A | * Filamin A; Domains – ABD 1-278; 3-5 478-766; 10 1158-1252; 16 1772-1861; 17 1862-1955; 18 1954-2053; 19 2054-2141; 20 2142-2235; 21 2236-2329; 23 2427-2522; 24 2559-2647 | ||
**[[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD - human<br /> | |||
**[[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br /> | |||
**[[3hoc]] – hFLNA ABD (mutant)<br /> | **[[3hoc]] – hFLNA ABD (mutant)<br /> | ||
**[[6d8c]] - hFLNA ABD (mutant) + actin + phalloidin – Cryo EM<br /> | |||
**[[4m9p]] - hFLNA domains 3-5<br /> | **[[4m9p]] - hFLNA domains 3-5<br /> | ||
**[[6ew1]] - hFLNA domains 3-5 (mutant)<br /> | |||
**[[3rgh]] - hFLNA domain 10<br /> | |||
**[[2aav]] - hFLNA domain 17 – NMR<br /> | **[[2aav]] - hFLNA domain 17 – NMR<br /> | ||
**[[2bp3]] - hFLNA domain 17+GPIB peptide<br /> | **[[2bp3]] - hFLNA domain 17+GPIB peptide<br /> | ||
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**[[2w0p]], [[2mtp]] - hFLNA domain 21+migfilin peptide<br /> | **[[2w0p]], [[2mtp]] - hFLNA domain 21+migfilin peptide<br /> | ||
**[[2jf1]], [[2brq]] - hFLNA domain 21+integrin peptide<br /> | **[[2jf1]], [[2brq]] - hFLNA domain 21+integrin peptide<br /> | ||
**[[3isw]] – hFLNA domain 21+CFTR peptide <br /> | |||
**[[2k3t]] - hFLNA domain 23 – NMR<br /> | **[[2k3t]] - hFLNA domain 23 – NMR<br /> | ||
**[[3cnk]] - hFLNA | **[[3cnk]] - hFLNA domain 24<br /> | ||
* Filamin B | * Filamin B | ||
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* Filamin C | * Filamin C | ||
**[[2k9u]] – hFLNC+migfilin peptide<br /> | **[[3v8o]] - hFLNC domains 4,5 <br /> | ||
**[[4mgx]] - hFLNC domains 4,5 + platelet glycoprotein peptide<br /> | |||
**[[2k9u]] – hFLNC residues 919-1032 +migfilin peptide<br /> | |||
**[[2d7m]], [[2d7n]], [[2d7o]], [[2d7p]] - hFLNC domains 14, 16, 17, 22 - NMR<br /> | **[[2d7m]], [[2d7n]], [[2d7o]], [[2d7p]] - hFLNC domains 14, 16, 17, 22 - NMR<br /> | ||
**[[2nqc]] - hFLNC domain 21<br /> | **[[2nqc]] - hFLNC domain 21<br /> | ||
**[[2d7q]] - hFLNC domain 23 – NMR<br /> | **[[2d7q]] - hFLNC domain 23 – NMR<br /> | ||
**[[1v05]] - hFLNC rod domain<br /> | |||
**[[1v05]] - hFLNC | |||
* Other Filamins | * Other Filamins | ||
