6k5l: Difference between revisions
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The | ==The crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coli== | ||
<StructureSection load='6k5l' size='340' side='right'caption='[[6k5l]], [[Resolution|resolution]] 2.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6k5l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K5L FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k5l OCA], [http://pdbe.org/6k5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k5l RCSB], [http://www.ebi.ac.uk/pdbsum/6k5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k5l ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/A0A1Z3UWE5_ECOLX A0A1Z3UWE5_ECOLX]] Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.[HAMAP-Rule:MF_00747][SAAS:SAAS00963147] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Jia, Z]] | [[Category: Jia, Z]] | ||
[[Category: Lei, Z]] | [[Category: Lei, Z]] | ||
[[Category: Zhang, X]] | [[Category: Zhang, X]] | ||
[[Category: Zheng, J]] | [[Category: Zheng, J]] | ||
[[Category: Hydrolase]] | |||
[[Category: Kinase]] | |||
[[Category: Phosphatase]] | |||
Revision as of 05:52, 3 July 2019
The crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coli
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