6n8y: Difference between revisions
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==Hsp90-beta bound to PU-11-trans== | |||
<StructureSection load='6n8y' size='340' side='right'caption='[[6n8y]], [[Resolution|resolution]] 1.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6n8y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N8Y FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KFY:9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine'>KFY</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n8y OCA], [http://pdbe.org/6n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n8y RCSB], [http://www.ebi.ac.uk/pdbsum/6n8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n8y ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Gewirth, D T]] | |||
[[Category: Huck, J D]] | |||
[[Category: Que, N L.S]] | |||
[[Category: Cancer]] | |||
[[Category: Chaperone]] | |||
[[Category: Chaperone-chaperone inhibitor complex]] | |||
[[Category: Cytosol]] | |||
[[Category: Hsp90]] | |||
[[Category: Inhibitor]] | |||
