6ob6: Difference between revisions
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==Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned== | |||
<StructureSection load='6ob6' size='340' side='right'caption='[[6ob6]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ob6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OB6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBM:6-{[(4-nitrophenyl)methyl]sulfanyl}-9-beta-D-ribofuranosyl-9H-purine'>NBM</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ob6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ob6 OCA], [http://pdbe.org/6ob6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ob6 RCSB], [http://www.ebi.ac.uk/pdbsum/6ob6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ob6 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/S29A1_HUMAN S29A1_HUMAN]] Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Lee, S Y]] | |||
[[Category: Wright, N J]] | |||
[[Category: Adenosine reuptake inhibitor]] | |||
[[Category: Adenosine transport]] | |||
[[Category: Ent]] | |||
[[Category: Hent1]] | |||
[[Category: Nbmpr]] | |||
[[Category: Nbti]] | |||
[[Category: Nucleoside transport]] | |||
[[Category: Nucleoside-drug transport]] | |||
[[Category: Slc29]] | |||
[[Category: Transport protein]] | |||
Revision as of 05:57, 3 July 2019
Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned
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