6qjo: Difference between revisions
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==DNA containing both right- and left-handed parallel-stranded G-quadruplexes== | |||
<StructureSection load='6qjo' size='340' side='right'caption='[[6qjo]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6qjo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJO FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qjo OCA], [http://pdbe.org/6qjo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qjo RCSB], [http://www.ebi.ac.uk/pdbsum/6qjo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qjo ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Analogous to the B- and Z-DNA structures in double-helix DNA, there exist both right- and left-handed quadruple-helix (G-quadruplex) DNA. Numerous conformations of right-handed and a few left-handed G-quadruplexes were previously observed, yet they were always identified separately. Here, we present the NMR solution and X-ray crystal structures of a right- and left-handed hybrid G-quadruplex. The structure reveals a stacking interaction between two G-quadruplex blocks with different helical orientations and displays features of both right- and left-handed G-quadruplexes. An analysis of loop mutations suggests that single-nucleotide loops are preferred or even required for the left-handed G-quadruplex formation. The discovery of a right- and left-handed hybrid G-quadruplex further expands the polymorphism of G-quadruplexes and is potentially useful in designing a left-to-right junction in G-quadruplex engineering. | |||
NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes.,Winnerdy FR, Bakalar B, Maity A, Vandana JJ, Mechulam Y, Schmitt E, Phan AT Nucleic Acids Res. 2019 Jun 19. pii: 5520578. doi: 10.1093/nar/gkz349. PMID:31216034<ref>PMID:31216034</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6qjo" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Bakalar, B]] | |||
[[Category: Maity, A]] | |||
[[Category: Mechulam, Y]] | |||
[[Category: Phan, A T]] | |||
[[Category: Schmitt, E]] | |||
[[Category: Vandana, J J]] | |||
[[Category: Winnerdy, F R]] | |||
[[Category: Dna]] | |||
[[Category: G-quadruplex left-handed right-handed]] | |||
Revision as of 06:01, 3 July 2019
DNA containing both right- and left-handed parallel-stranded G-quadruplexes
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