2v5p: Difference between revisions

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[[Image:2v5p.jpg|left|200px]]
[[Image:2v5p.jpg|left|200px]]


{{Structure
<!--
|PDB= 2v5p |SIZE=350|CAPTION= <scene name='initialview01'>2v5p</scene>, resolution 4.10&Aring;
The line below this paragraph, containing "STRUCTURE_2v5p", creates the "Structure Box" on the page.
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC5:Bma+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Chain+B'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Chain+B'>AC7</scene> and <scene name='pdbsite=AC8:Bma+Binding+Site+For+Chain+A'>AC8</scene>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_2v5p| PDB=2v5p  | SCENE= }}  
|RELATEDENTRY=[[1gf2|1GF2]], [[1igl|1IGL]], [[1e6f|1E6F]], [[1gp0|1GP0]], [[1gp3|1GP3]], [[1gqb|1GQB]], [[1jpl|1JPL]], [[1jwg|1JWG]], [[1lf8|1LF8]], [[2cnj|2CNJ]], [[2v5n|2V5N]], [[2v5o|2V5O]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5p OCA], [http://www.ebi.ac.uk/pdbsum/2v5p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v5p RCSB]</span>
}}


'''COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II'''
'''COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II'''
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[[Category: Wallace, J C.]]
[[Category: Wallace, J C.]]
[[Category: Zaccheo, O J.]]
[[Category: Zaccheo, O J.]]
[[Category: beta barrel]]
[[Category: Beta barrel]]
[[Category: cation independent mannose 6-phosphate]]
[[Category: Cation independent mannose 6-phosphate]]
[[Category: fibronectin type ii]]
[[Category: Fibronectin type ii]]
[[Category: glycoprotein]]
[[Category: Glycoprotein]]
[[Category: insulin-like growth factor]]
[[Category: Insulin-like growth factor]]
[[Category: lysosome]]
[[Category: Lysosome]]
[[Category: membrane]]
[[Category: Membrane]]
[[Category: phosphorylation]]
[[Category: Phosphorylation]]
[[Category: polymorphism]]
[[Category: Polymorphism]]
[[Category: receptor]]
[[Category: Receptor]]
[[Category: receptor/glycoprotein complex]]
[[Category: Receptor/glycoprotein complex]]
[[Category: transmembrane]]
[[Category: Transmembrane]]
[[Category: transport]]
[[Category: Transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:30:17 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:08:33 2008''

Revision as of 06:30, 24 April 2008

File:2v5p.jpg

Template:STRUCTURE 2v5p

COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II


Overview

Embryonic development and normal growth require exquisite control of insulin-like growth factors (IGFs). In mammals the extracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-binding function and is termed type II IGF receptor (IGF2R). IGF2R sequesters IGF-II; imbalances occur in cancers and IGF2R is implicated in tumour suppression. We report crystal structures of IGF2R domains 11-12, 11-12-13-14 and domains 11-12-13/IGF-II complex. A distinctive juxtaposition of these domains provides the IGF-II-binding unit, with domain 11 directly interacting with IGF-II and domain 13 modulating binding site flexibility. Our complex shows that Phe19 and Leu53 of IGF-II lock into a hydrophobic pocket unique to domain 11 of mammalian IGF2Rs. Mutagenesis analyses confirm this IGF-II 'binding-hotspot', revealing that IGF-binding proteins and IGF2R have converged on the same high-affinity site.

About this Structure

2V5P is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and functional analysis of the IGF-II/IGF2R interaction., Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY, EMBO J. 2008 Jan 9;27(1):265-76. Epub 2007 Nov 29. PMID:18046459 Page seeded by OCA on Thu Apr 24 09:30:17 2008

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