6a8o: Difference between revisions
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==Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16== | |||
<StructureSection load='6a8o' size='340' side='right'caption='[[6a8o]], [[Resolution|resolution]] 2.77Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6a8o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A8O FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a8o OCA], [http://pdbe.org/6a8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a8o RCSB], [http://www.ebi.ac.uk/pdbsum/6a8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a8o ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/KLKB1_MOUSE KLKB1_MOUSE]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Plasma kallikrein]] | |||
[[Category: Huang, M]] | [[Category: Huang, M]] | ||
[[Category: Jiang, L]] | [[Category: Jiang, L]] | ||
[[Category: Xu, M]] | [[Category: Xu, M]] | ||
[[Category: Hydrolase]] | |||
[[Category: Murine plasma kallikrein]] | |||
[[Category: Serine protease]] | |||
Revision as of 05:38, 10 July 2019
Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16
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