6fm4: Difference between revisions
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The | ==The crystal structure of S. aureus Gyrase complex with ID-130 and DNA== | ||
<StructureSection load='6fm4' size='340' side='right'caption='[[6fm4]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6fm4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FM4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene>, <scene name='pdbligand=DU5:~{N}-[3-(4-isoquinolin-1-ylpiperazin-1-yl)propyl]benzamide'>DU5</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fm4 OCA], [http://pdbe.org/6fm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fm4 RCSB], [http://www.ebi.ac.uk/pdbsum/6fm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fm4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Garofalo, B]] | |||
[[Category: Mancini, F]] | |||
[[Category: Mangano, G]] | |||
[[Category: Ombrato, R]] | |||
[[Category: Bacterial topoisomerase]] | |||
[[Category: Gyrase]] | |||
[[Category: Isomerase]] | |||
[[Category: Nbti]] | |||
Revision as of 05:41, 10 July 2019
The crystal structure of S. aureus Gyrase complex with ID-130 and DNA
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