6p28: Difference between revisions
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==Crystal structure of the MIR domain (aa 337-532) of the S. cerevisiae mannosyltransferase Pmt2== | |||
<StructureSection load='6p28' size='340' side='right'caption='[[6p28]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6p28]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P28 FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dolichyl-phosphate-mannose--protein_mannosyltransferase Dolichyl-phosphate-mannose--protein mannosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.109 2.4.1.109] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p28 OCA], [http://pdbe.org/6p28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p28 RCSB], [http://www.ebi.ac.uk/pdbsum/6p28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p28 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PMT2_YEAST PMT2_YEAST]] Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT5 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export.<ref>PMID:15377669</ref> <ref>PMID:18182384</ref> <ref>PMID:21147851</ref> <ref>PMID:8543034</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dolichyl-phosphate-mannose--protein mannosyltransferase]] | |||
[[Category: Large Structures]] | |||
[[Category: Bai, L]] | |||
[[Category: Li, H]] | [[Category: Li, H]] | ||
[[Category: | [[Category: Complex]] | ||
[[Category: Glycosylation]] | |||
[[Category: Transferase]] | |||
Revision as of 05:52, 10 July 2019
Crystal structure of the MIR domain (aa 337-532) of the S. cerevisiae mannosyltransferase Pmt2
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