6kbr: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6kbr is ~~ON HOLD~~

==Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex==

~~Authors~~: ~~Kawaguchi~~, Y., ~~Nishimiya~~, D.

== Structural highlights ==

<table><tr><td colspan='2'>[[6kbr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KBR FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~Human KLK4~~ and ~~SPINK2 derived KLK4 inhibitor complex~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kbr OCA], [http://pdbe.org/6kbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kbr RCSB], [http://www.ebi.ac.uk/pdbsum/6kbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kbr ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>

== Function ==

[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Kawaguchi, Y]]

[[Category: Nishimiya, D]]

[[Category: Cystine knot protein]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Protease inhibitor]]

[[Category: Protein binding]]

[[Category: Protein engineering]]

[[Category: Structural analysis]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6kbr is ON HOLD
+==Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex==
+<StructureSection load='6kbr' size='340' side='right'caption='[[6kbr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Kawaguchi, Y., Nishimiya, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6kbr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KBR FirstGlance]. <br>
-Description: Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kbr OCA], [http://pdbe.org/6kbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kbr RCSB], [http://www.ebi.ac.uk/pdbsum/6kbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kbr ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Kawaguchi, Y]]
 [[Category: Nishimiya, D]]
+[[Category: Cystine knot protein]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Protease inhibitor]]
+[[Category: Protein binding]]
+[[Category: Protein engineering]]
+[[Category: Structural analysis]]