6nnd: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6nnd is ~~ON HOLD~~

==Structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and dihydrofolate==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6nnd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NND OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NND FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6nnc|6nnc]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nnd OCA], [http://pdbe.org/6nnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nnd RCSB], [http://www.ebi.ac.uk/pdbsum/6nnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nnd ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

__TOC__

</StructureSection>

[[Category: Dihydrofolate reductase]]

[[Category: Large Structures]]

[[Category: Chavez-Pacheco, S M]]

[[Category: Dias, M V.B]]

[[Category: Ribeiro, J A]]

[[Category: Antifolate]]

[[Category: Biosynthetic protein]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6nnd is ON HOLD
+==Structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and dihydrofolate==
+<StructureSection load='6nnd' size='340' side='right'caption='[[6nnd]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nnd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NND FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nnc|6nnc]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nnd OCA], [http://pdbe.org/6nnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nnd RCSB], [http://www.ebi.ac.uk/pdbsum/6nnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nnd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
+__TOC__
+</StructureSection>
+[[Category: Dihydrofolate reductase]]
+[[Category: Large Structures]]
+[[Category: Chavez-Pacheco, S M]]
+[[Category: Dias, M V.B]]
+[[Category: Ribeiro, J A]]
+[[Category: Antifolate]]
+[[Category: Biosynthetic protein]]