6nne: Difference between revisions
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==Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with diaverdine== | |||
<StructureSection load='6nne' size='340' side='right'caption='[[6nne]], [[Resolution|resolution]] 1.59Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NNE FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=KUP:5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine'>KUP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nne OCA], [http://pdbe.org/6nne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nne RCSB], [http://www.ebi.ac.uk/pdbsum/6nne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nne ProSAT]</span></td></tr> | ||
[[Category: Dias, M | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/A5U6B6_MYCTA A5U6B6_MYCTA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dihydrofolate reductase]] | |||
[[Category: Large Structures]] | |||
[[Category: Chavez-Pacheco, S M]] | |||
[[Category: Dias, M V.B]] | |||
[[Category: Ribeiro, J A]] | |||
[[Category: Antifolate]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 10:46, 17 July 2019
Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with diaverdine
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